Reading the evidence
Trial phases, RCTs, the evidence hierarchy and common pitfalls.
- ArticleConflicts of Interest in Research
Who funded the study? That single question can change how you read almost any cannabinoid or phytomedicine research. Here's how to spot funding bias.
- ArticleConfounding Variables Explained
Confounding variables are the reason a convincing study can still be wrong. Here's how to spot them — and why it matters in plant-based medicine research.
- ArticleHow Clinical Trials Move from Lab to Patient
How clinical trials move from the lab to patients: preclinical work, the phases, regulator review and why the process takes time, in plain language.
- ArticleMeta-Analysis: Pooling the Evidence
Meta-analyses pool data from dozens of studies — but the method has real limits. Here's how to read one without being misled by the headline.
- ArticleObservational Studies vs RCTs
Observational studies vs RCTs answer different questions. Knowing which is which changes how much weight you should give any headline claim.
- ArticlePlacebo, Blinding and Bias
Placebo, blinding and bias shape how every trial result reads. Learn how study design can inflate findings and what to check in a methods section.
- ArticlePreclinical vs Clinical Research
Preclinical research and clinical trials are not the same thing. Here's how to tell them apart — and why that gap matters more than most headlines let on.
- ArticlePre-Registration and Publication Bias
Publication bias shapes what science "knows". Here's how pre-registration works, why it matters, and how to spot studies that may have moved the goalposts.
- ArticleRandomised Controlled Trials Explained
RCTs are the gold standard for testing whether something works — but they have real limits. Here's how to read them without being fooled.
- ArticleReading a Systematic Review
Systematic reviews sit at the top of the evidence pyramid — but only when done well. Here's how to read one without being misled by headlines.
- ArticleReal-World Evidence vs Trial Data
RCT data and real-world evidence each tell a different story. Here's how to read both without getting fooled — and why the gap between them matters.
- ArticleSample Size and Statistical Power
Sample size and statistical power shape whether a study's results mean anything at all. Here's how to spot the difference between signal and noise.
- ArticleSurrogate vs Clinical Endpoints
Surrogate endpoints sound rigorous — but they often aren't. Here's how to tell whether a study measured something that actually matters.
- ArticleThe Endocannabinoid System, Explained for Non-Scientists
A plain-language introduction to the endocannabinoid system, the body's internal signalling network and the reason cannabinoids interact with us at all.
- ArticleThe Hierarchy of Evidence
Not all studies are created equal. Here's how to read the hierarchy of evidence without getting fooled by headlines, hype, or a single promising trial.
- ArticleThe Phases of a Clinical Trial
Clinical trials run in phases for good reason. Here's what each one actually tests, why they take so long, and how to read the evidence without being misled.
- ArticleUnderstanding Statistical Significance
Statistical significance explained: what p-values, sample sizes and confidence intervals mean, and how to read study headlines more honestly.
- ArticleWhat "Investigational" Means
What investigational means in drug regulation: a plain guide to phases, TGA pathways and how to read the word in cannabinoid and peptide research.
- ArticleWhy Anecdotes Are Not Evidence
Anecdotes feel compelling, but they're not evidence. Here's how to spot the difference — and why it matters when you're reading cannabinoid or phytomedicine research.